Bioactive Small Molecules
Medchemexpress LLC Boc-D-alaninol | 106391-86-0 | 175.23 | 10 G
Boc-D-alaninol is a laboratory chemical primarily used in the manufacture of various substances. It is supplied as a white to off-white solid. This product has not been fully validated for medical applications and is for research use only.
- High purity: 99.89% (GC)
- Molecular weight: 175.23
- Optimal storage for powder: -20°C for 3 years, or 4°C for 2 years
- Optimal storage in solvent: -80°C for 6 months, or -20°C for 1 month
- For research use only
Cayman Chemical ANTIBODY CMPF-d5 500UG
An internal standard for the quantification of CMPF by GC- or LC-MS
Cayman Chemical ZelkovamycIn 5mg
A cyclic peptide antibiotic; inhibits growth of X. oryzae, P. oryzae, S. aureus, and A. laidlawii from 0.01-300 μg/ml
Medchemexpress LLC Sinapaldehyde | 4206-58-0 | 208.21 | 50 MG
Sinapaldehyde is a methoxyphenol extracted from various plants, functioning as a selective COX-2 inhibitor. It demonstrates antibacterial, anti-inflammatory, and antioxidant properties, making it suitable for various research applications.
- Selective COX-2 inhibitor (IC50: 47.8 μM)
- Scavenges DPPH free radicals (IC50: 172 μM)
- Effective against Gram-negative and Gram-positive bacteria, including MRSA
- Inhibits generation of NO and ROS
- Reduces production of IL-6 and TNF-α
- Inhibits expression of iNOS and COX-2
- Inhibits phosphorylation of p65, ERK1/2, and SAPK/JNK
- Solid appearance, white to yellow color
- Soluble in DMSO (50 mg/mL)
Medchemexpress LLC AK59 | 99.0% | 429.41 | 5 MG
AK59 is a STING degrader that operates by utilizing HERC4, a hect domain E3 ligase. It is intended for use in the study of autoimmune diseases and cancer.
- STING degrader
- Leverages HERC4, a hect domain E3 ligase
- Applicable in the study of autoimmune diseases
- Applicable in the study of cancer
- For research use only
Lkt Laboratories Cinacalcet Hydrochloride, ≥99%, 5MG
Ca2+-sensing receptor agonist. CAS: 364782-34-3. Additional sizes available upon request. Ships from Saint Paul, MN.
Cayman Chemical ANTIBODY WT161 5mg
A potent inhibitor of HDAC6 (IC50 = 0.40 nM); selective for HDAC6 over HDAC3 (IC50 = 51.61 nM); induces α-tubulin acetylation, an HDAC6-dependent process, with minimal effect on global lysine acetylation; inhibits growth of patient-derived multiple myeloma cell lines (IC50s = 1.5-4.7 μM); enhances cytotoxicity of bortezomib and carfilzomib against patient-derived multiple myeloma cells; decreases tumor size in a human MM.1S multiple myeloma mouse xenograft model when administered in combination with bortezomib at doses of 50 and 0.5 mg/kg, respectively
Cayman Chemical ANTIBODY PoloppIn 25mg
An inhibitor of the Plk1-Plk1-binding phosphopeptide protein-peptide interaction (IC50 = 26.9 µM); induces mitotic arrest in HeLa cells (EC50 = 29.9 µM); inhibits cell growth in murine pancreatic organoids expressing mutant K-Ras (GI50s = 22.92-28.39 µM)
Sigma Aldrich Fine Chemicals Biosciences Nebivolol hydrochloride United States Pharmacopeia (USP) Reference Standard | 152520-56-4 | 150MG
Nebivolol hydrochloride United States Pharmacopeia (USP) Reference Standard | Mol Wt: 441.9 | 152520-56-4 | 150MG
Cayman Chemical ANTIBODY LSN2814617 10mg
A positive allosteric modulator of mGluR5 receptors; potentiates glutamate-induced calcium mobilization in MCB3901 cells expressing human mGluR5 (EC50 = 52 nM); increases rat hippocampal mGluR5 receptor occupancy (ED50 = 13 mg/kg); increases wakefulness and decreases NREM and REM sleep in rats at 0.3, 1, and 3 mg/kg
Apexbio Technology LLC AZD-5597 924641-59-8 5mg
AZD-5597 (CAS 924641-59-8) is an imidazole pyrimidine amide compound that acts as a potent inhibitor of cyclin-dependent kinases CDK1 and CDK2 exhibiting an IC50 of 2 nM for both enzymes CDKs are serine/threonine protein kinases involved in regulation of the cell cycle transcription mRNA processing and neuronal differentiation In cellular studies AZD-5597 demonstrates strong antiproliferative activity such as an MIC50 of 0 039 M in LoVo cells The compound displays high aqueous solubility stability under various conditions and does not inhibit CYP enzymes Preclinical pharmacokinetic evaluations reveal favorable properties supporting its utility as a research tool for investigating CDK inhibition and antitumor activity
Apexbio Technology LLC Nicotine Difartrate 1g
A8482 is a small molecule utilized in biomedical research for its modulatory effects on cellular signaling pathways Although its precise biological target and mechanism of action have not been fully delineated A8482 has been employed in studies investigating intracellular processes relevant to disease models This compound facilitates exploration of signal transduction mechanisms and allows for the evaluation of pathway-specific responses in cellular assays A8482 is valuable for researchers aiming to dissect molecular events underlying physiological and pathological conditions
Medchemexpress LLC Gly-gly-phe-gly-nh-o-co-exatecan | 1599440-12-6 | 95.9% | 840.85 | C42H45FN8O10 | 5 MG
Gly-Gly-Phe-Gly-NH-O-CO-Exatecan is a drug-linker conjugate intended for antibody-drug conjugate (ADC) research. It couples a cleavable Gly-Gly-Phe-Gly peptide linker to the topoisomerase I inhibitor exatecan, enabling targeted delivery of a cytotoxic payload. Supplied as an off-white to light yellow solid with supporting COA and handling documentation for research use.
Apexbio Technology LLC GBR 12935 dihydrochloride 67469-81-2 50mg
GBR 12935 dihydrochloride is a small-molecule inhibitor targeting the dopamine transporter (DAT) It is designed to inhibit DAT-mediated dopamine reuptake thereby modulating dopaminergic signaling and increasing extracellular dopamine levels GBR 12935 dihydrochloride exerts its biological activity primarily through direct blockade of neuronal dopamine uptake at the synaptic cleft Based on these pharmacological properties GBR 12935 dihydrochloride holds research potential in studies of dopaminergic signaling reward pathways addiction behaviors dopamine-related neurodegeneration and dopamine transporter function
Medchemexpress LLC Myosmine | 532-12-7 | 146.19 | 1 ML
Myosmine is a specific tobacco alkaloid found in nuts and nut products. It acts as an nAChR activator and has a low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM. It is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N'-nitrosonornicotine. This product is for research use only.
- Acts as an nAChR activator
- Low affinity for a4b2 nicotinic acetylcholinergic receptors
- Easily nitrosated to form carcinogens
- For research use only